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1

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms

Wahlman, Carrie, Doyle, Timothy M., Little, Joshua W., Luongo, Livio, Janes, Kali, Chen, Zhoumou, Esposito, Emanuela, Tosh, Dilip K., Cuzzocrea, Salvatore, Jacobson, Kenneth A., Salvemini, Daniela

Journal:

Year:

2018

Language:

english

File:

PDF, 2.37 MB

english, 2018

2

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

Stockstill, Katherine, Doyle, Timothy M., Yan, Xisheng, Chen, Zhoumou, Janes, Kali, Little, Joshua W., Braden, Kathryn, Lauro, Filomena, Giancotti, Luigino Antonio, Harada, Caron Mitsue, Yadav, Ruchi,

Journal:

Journal of Experimental Medicine

Year:

2018

Language:

english

File:

PDF, 2.10 MB

english, 2018

3

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

Doyle, Timothy M., Janes, Kali, Chen, Zhoumou, Grace, Peter M., Esposito, Emanuela, Cuzzocrea, Salvatore, Largent-Milnes, Tally M., Neumann, William L., Watkins, Linda R., Spiegel, Sarah, Vanderah, To

Journal:

Year:

2020

File:

PDF, 1.24 MB

2020

4

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Doyle, Timothy M., Hutchinson, Mark R., Braden, Kathryn, Janes, Kali, Staikopoulos, Vicky, Chen, Zhoumou, Neumann, William L., Spiegel, Sarah, Salvemini, Daniela

Journal:

Journal of Neuroinflammation

Year:

2020

File:

PDF, 993 KB

2020

5

Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers

Rausaria, Smita, Kamadulski, Andrew, Rath, Nigam P., Bryant, Leesa, Chen, Zhoumou, Salvemini, Daniela, Neumann, William L.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.38 MB

english, 2011

6

NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing

Zhoumou Chen, Carolina Muscoli, Tim Doyle, L. Bryant, Salvatore Cuzzocrea, Vincenzo Mollace, Rosanna Mastroianni, Emanuela Masini, Daniela Salvemini

Journal:

Year:

2010

Language:

english

File:

PDF, 408 KB

english, 2010

7

Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats

Tim Doyle, Amanda Finley, Zhoumou Chen, Daniela Salvemini

Journal:

Year:

2011

Language:

english

File:

PDF, 387 KB

english, 2011

8

Effect of MTP on TNF-α in Perfused Rat Liver after Bacteremia and Ischemia/Reperfusion

Rodney M. Durham, Andrew J. Lechner, Cheryl A. Johanns, Zhoumou Chen, George M. Matuschak

Journal:

Journal of Surgical Research

Year:

1998

Language:

english

File:

PDF, 130 KB

english, 1998

9

Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance

Tim Doyle, Leesa Bryant, Carolina Muscoli, Salvatore Cuzzocrea, Emanuela Esposito, Zhoumou Chen, Daniela Salvemini

Journal:

Neuroscience Letters

Year:

2010

Language:

english

File:

PDF, 170 KB

english, 2010

10

Sphingosine-1-phosphate acting via the S1P1 receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

Tim Doyle, Zhoumou Chen, Lina M. Obeid, Daniela Salvemini

Journal:

Neuroscience Letters

Year:

2011

Language:

english

File:

PDF, 431 KB

english, 2011

11

Retooling Manganese(III) Porphyrin-Based Peroxynitrite Decomposition Catalysts for Selectivity and Oral Activity: A Potential New Strategy for Treating Chronic Pain

Rausaria, Smita, Ghaffari, Mahsa M. E., Kamadulski, Andrew, Rodgers, Kenny, Bryant, Leesa, Chen, Zhoumou, Doyle, Tim, Shaw, Michael J., Salvemini, Daniela, Neumann, William L.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

12

DDD-028: A potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain

Rajagopalan, Parthasarathi, Tracey, Heather, Chen, Zhoumou, Bandyopadhyaya, Acintya, Veeraraghavan, Sridhar, Rajagopalan, Desikan R., Salvemini, Daniela, McPhee, Ian, Viswanadha, Srikant, Rajagopalan,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 301 KB

english, 2014

13

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

Janes, Kali, Little, Joshua W., Li, Chao, Bryant, Leesa, Chen, Collin, Chen, Zhoumou, Kamocki, Krzysztof, Doyle, Timothy, Snider, Ashley, Esposito, Emanuela, Cuzzocrea, Salvatore, Bieberich, Erhard, O

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 2.07 MB

english, 2014

14

Extended N6 substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor

Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Moss, Steven M., Gao, Zhan-Guo, Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 814 KB

english, 2014

15

Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A 3 adenosine receptor agonists

Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Crane, Steven, Lloyd, John, Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

Year:

2015

Language:

english

File:

PDF, 5.44 MB

english, 2015

16

Rigidified A 3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

Tosh, Dilip K., Crane, Steven, Chen, Zhoumou, Paoletta, Silvia, Gao, Zhan-Guo, Gizewski, Elizabeth, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

17

Purine ( N )-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A 3 Adenosine Receptor Agonists

Tosh, Dilip K., Ciancetta, Antonella, Warnick, Eugene, O’Connor, Robert, Chen, Zhoumou, Gizewski, Elizabeth, Crane, Steven, Gao, Zhan-Guo, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 4.41 MB

english, 2016

18

Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: Correlation with preserved circulating catecholamines*

Macarthur, Heather, Couri, Daniel M., Wilken, Gerald H., Westfall, Thomas C., Lechner, Andrew J., Matuschak, George M., Chen, Zhoumou, Salvemini, Daniela

Journal:

Critical Care Medicine

Year:

2003

Language:

english

File:

PDF, 406 KB

english, 2003

19

MICROARRAY ANALYSIS OF EARLY POSTBACTEREMIC LIVER AND LUNG GENE EXPRESSION FOLLOWING HYPOXIC STRESS

Matuschak, George M, Doyle, Tomothy M, Chen, Zhoumou, Lechner, Andrew J

Journal:

Critical Care Medicine

Year:

2004

Language:

english

File:

PDF, 576 KB

english, 2004

20

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters

Tosh, Dilip K., Janowsky, Aaron, Eshleman, Amy J., Warnick, Eugene, Gao, Zhan-Guo, Chen, Zhoumou, Gizewski, Elizabeth, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

21

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

Grenald, Shaness A., Doyle, Timothy M., Zhang, Hong, Slosky, Lauren M., Chen, Zhoumou, Largent-Milnes, Tally M., Spiegel, Sarah, Vanderah, Todd W., Salvemini, Daniela

Journal:

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

22

Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism

Finley, Amanda, Chen, Zhoumou, Esposito, Emanuela, Cuzzocrea, Salvatore, Sabbadini, Roger, Salvemini, Daniela, Baccei, Mark L.

Journal:

Year:

2013

Language:

english

File:

PDF, 493 KB

english, 2013

23

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Chen, Zhoumou, Doyle, Timothy M., Luongo, Livio, Largent-Milnes, Tally M., Giancotti, Luigino Antonio, Kolar, Grant, Squillace, Silvia, Boccella, Serena, Walker, John K., Pendleton, Alexander, Spiegel

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 1.15 MB

english, 2019

24

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents

Stockstill, Katherine, Wahlman, Carrie, Braden, Kathryn, Chen, Zhoumou, Yosten, Gina L., Tosh, Dilip K., Jacobson, Kenneth A., Doyle, Timothy M., Samson, Willis K., Salvemini, Daniela

Journal:

Year:

2019

File:

PDF, 1.00 MB

2019

25

P2Y 14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

Mufti, Fatma, Jung, Young-Hwan, Giancotti, Luigino Antonio, Yu, Jinha, Chen, Zhoumou, Phung, Ngan B., Jacobson, Kenneth A., Salvemini, Daniela

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.10 MB

2020

26

Design and in vivo activity of A3 adenosine receptor agonist prodrugs

Suresh, R. Rama, Jain, Shanu, Chen, Zhoumou, Tosh, Dilip K., Ma, Yanling, Podszun, Maren C., Rotman, Yaron, Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

Purinergic Signalling

Year:

2020

File:

PDF, 3.72 MB

2020

27

Exploration of Alternative Scaffolds for P2Y 14 Receptor Antagonists Containing a Biaryl Core

Jung, Young-Hwan, Yu, Jinha, Wen, Zhiwei, Salmaso, Veronica, Karcz, Tadeusz P., Phung, Ngan B., Chen, Zhoumou, Duca, Sierra, Bennett, John M., Dudas, Steven, Salvemini, Daniela, Gao, Zhan-Guo, Cook, D

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 4.19 MB

2020

28

GPR183-oxysterol axis in spinal cord contributes to neuropathic pain

Braden, Kathryn, Giancotti, Luigino Antonio, Chen, Zhoumou, DeLeon, Chelsea, Latzo, Nick, Boehm, Terri, D'Cunha, Napoleon, Thompson, Bonne M., Doyle, Timothy M., McDonald, Jeffrey G., Walker, John K.,

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2020

File:

PDF, 7.91 MB

2020